| Item type |
[ELS]紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2016-07-25 |
| タイトル |
|
|
タイトル |
アルコール摂取時の代謝変動に及ぼす内分泌の影響(第2報)性差について |
| タイトル |
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|
タイトル |
Effects of Hormonal Agents on Metabolic Changes Induced by Acute Alcohol lngestion in Rats II : The Effects of Sex Distinction |
|
言語 |
en |
| 言語 |
|
|
言語 |
jpn |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 雑誌書誌ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00039943 |
| 論文名よみ |
|
|
タイトル |
〓 |
| 著者 |
小住, フミ子
鮫島, かな子
OZUMI, Fumiko
SAMESHIMA, Kanako
|
| 抄録(英) |
|
|
内容記述タイプ |
Other |
|
内容記述 |
It is well known that excessive ingestion of alcohol is associated with derangements in liver function and the development of liver disease. Nevertheless, the exact mechanisms whereby the intake of alcohol produces the fatty liver or liver diseases have remained to be solved. The experiments reported here were undertaken to ascertain the reason why the acute ethanol administration to rats maintained on an adequate diet results in the significant changes in hepatic triglyceride, plasma free acid, hepatic glycogen and blood glucose and why such effects were modified by endocrinic agents and sex distinction. The dose of ethanol administrated to rats was 6.0g/kg of Body weight. Castrated rats were used for the experiment after one month has elapsed after the operation, and all rats were sacrificed after 10 hours had elapsed since oral administration of ethanol. An increase of hepatic triglyceride level has been found after the acute ethanol intoxication. Female rats showed a more significant increase of hepatic triglyceride. Furthermore, a single intoxicating dose of ethanol induced the depletion of liver glycogen stores and hypoglycemia in intact rats and those with ovary extirpation, but hyperglycemia in those with testicle extirpation. The single administration of alcohol increased the plasma fatty acid level in normal rats but decreased the level in castrated ones. It is suggested that ethanol intoxication may cause the mobilization of fat from the depots to the liver and that adrenal hormones and sex distinction are involved in the mechanism of this mobilization. |
| 書誌情報 |
巻 24,
p. 15-22,
発行日 1974-02-01
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| 表示順 |
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内容記述タイプ |
Other |
|
内容記述 |
4 |
| アクセション番号 |
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|
内容記述タイプ |
Other |
|
内容記述 |
KJ00000066061 |
KJ00000066061.pdf (376.7 kB)
