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アルコール摂取時の代謝変動に及ぼす内分泌の影響について Effects of Hormonal Agents on Metabolic Changes Induced by Acute Alcohol Ingestion in Rats 〓 小住, フミ子 オズミ, フミコ 鮫島, かな子 サメシマ, カナコ OZUMI, Fumiko SAMESHIMA, Kanako It is well known that the excessive ingestion of alcohol is associated with derangements in liver function and the development of liver disease. Nevertheless, the exact mechanisms whereby the intake of alcohol produces a fatty liver or liver diseases have remained to be solved. The experiments reported here were undertaken to ascertain the reason why the acute ethanol administration to rats mainted on an adequate diet results in the significant changes in hepatic triglyceride, plasma free fatty acid, hepatic glycogen and blood glucose leves, and why such effects were modified by endocrine secretion. The dose of ethanol administrated to rats was 6.0g/kg of Body weight. All rats were sacrificed 10 hours after oral administration of ethanol. An increase of hepatic triglyceride level was found after the acute ethanol intoxication. Female rats showed a more significant increase of hepatic triglyceride. Furthermore, a single intoxicating dose of ethanol induced the depletion of liver glycogen stores and hypoglycemia both in male and female rats. In contrast to intact animals, rats treated with nor-adrenaline showed the more remakable increase of plasma fatty acid than control animals. It is suggested that ethanol intoxication may cause the mobilization of fat from the depots to the liver, and that adrenal hormones are involved in the mechanism of this mobilization. 4 KJ00000066053 1973-03-30 jpn departmental bulletin paper https://k-kentan.repo.nii.ac.jp/records/1131 AN00039943 23 11 19 https://k-kentan.repo.nii.ac.jp/record/1131/files/KJ00000066053.pdf application/pdf 514.1 kB 2016-07-25